abstract：:The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulation and identify their protein and metabolite targets. The hepatocarcinoma-derived HepG2 cell line under both normal and oxidative/nitrosative conditions by overexpression of NO synthase (NOS3) was used as experimental m...

journal_title：Redox biology

authors： López-Grueso MJ,González-Ojeda R,Requejo-Aguilar R,McDonagh B,Fuentes-Almagro CA,Muntané J,Bárcena JA,Padilla CA

更新日期：2019-02-01 00:00:00

abstract：:Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic acid (NO2-OA) is an el...

journal_title：Redox biology

authors： Jobbagy S,Vitturi DA,Salvatore SR,Turell L,Pires MF,Kansanen E,Batthyany C,Lancaster JR Jr,Freeman BA,Schopfer FJ

更新日期：2019-02-01 00:00:00

abstract：:Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling. However, excessive ROS generation (endogenous and exogenous) can create a state of redox imbalance leading to cellular and tissue damage (Ma and H...

journal_title：Redox biology

authors： Sivandzade F,Prasad S,Bhalerao A,Cucullo L

更新日期：2019-02-01 00:00:00

abstract：:Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced N...

journal_title：Redox biology

authors： Chen X,Xue H,Fang W,Chen K,Chen S,Yang W,Shen T,Chen X,Zhang P,Ling W

更新日期：2019-02-01 00:00:00

abstract：:Selenium-binding protein 1 (SELENBP1) has recently been reported to catalyse the oxidation of methanethiol, an organosulfur compound produced by gut microbiota. Two of the reaction products of methanethiol oxidation, hydrogen peroxide and hydrogen sulphide, serve as signalling molecules for cell differentiation. Indee...

journal_title：Redox biology

authors： Steinbrenner H,Micoogullari M,Hoang NA,Bergheim I,Klotz LO,Sies H

更新日期：2019-01-01 00:00:00

abstract：:A reliable and fast liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous determination of three oxidized nucleic acid damage products in urine, 8-oxoguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). We applied this me...

journal_title：Redox biology

authors： Shih YM,Cooke MS,Pan CH,Chao MR,Hu CW

更新日期：2019-01-01 00:00:00

abstract：:Mitochondrial derived reactive oxygen species (mtROS) are known for their signaling qualities in both physiology and pathology. To elucidate mitochondrial complex I-dependent ROS-signaling after lipopolysaccharide (LPS)-stimulation THP-1 macrophages with a knockdown of the transmembrane protein TMEM126B were generated...

journal_title：Redox biology

authors： Fuhrmann DC,Wittig I,Brüne B

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated that Mas receptor activation initiates an anti-oxidative and anti-apoptotic role in the brain. However, whether Mas activation can attenuate...

journal_title：Redox biology

authors： Mo J,Enkhjargal B,Travis ZD,Zhou K,Wu P,Zhang G,Zhu Q,Zhang T,Peng J,Xu W,Ocak U,Chen Y,Tang J,Zhang J,Zhang JH

更新日期：2019-01-01 00:00:00

abstract：:Despite extensive research that has been carried out over the past three decades in the field of renal ischaemia-reperfusion (I/R) injury, the pathogenic role of mitochondrial fission in renal I/R injury is poorly understood. The aim of our study is to investigate the molecular mechanism by which mammalian STE20-like ...

journal_title：Redox biology

authors： Li H,Feng J,Zhang Y,Feng J,Wang Q,Zhao S,Meng P,Li J

更新日期：2019-01-01 00:00:00

abstract：:The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide deficiency reduces sele...

journal_title：Redox biology

authors： Mayer K,Mundigl O,Kettenberger H,Birzele F,Stahl S,Pastan I,Brinkmann U

更新日期：2019-01-01 00:00:00

abstract：:Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Ma...

journal_title：Redox biology

authors： Narzt MS,Nagelreiter IM,Oskolkova O,Bochkov VN,Latreille J,Fedorova M,Ni Z,Sialana FJ,Lubec G,Filzwieser M,Laggner M,Bilban M,Mildner M,Tschachler E,Grillari J,Gruber F

更新日期：2019-01-01 00:00:00

abstract：:In order to overcome intercellular variability and thereby effectively assess signal propagation in biological networks it is imperative to simultaneously quantify multiple biological observables in single living cells. While fluorescent biosensors have been the tool of choice to monitor the dynamics of protein intera...

journal_title：Redox biology

authors： Corbat AA,Schuermann KC,Liguzinski P,Radon Y,Bastiaens PIH,Verveer PJ,Grecco HE

更新日期：2018-10-01 00:00:00

abstract：:Oxidative stress response in bacteria is mediated through coordination between the regulators of oxidant-remediation systems (e.g. OxyR, SoxR) and nucleoid condensation (e.g. Dps, Fis). However, these genetic factors are either absent or rendered non-functional in the human pathogen Mycobacterium tuberculosis (Mtb). T...

journal_title：Redox biology

authors： Chawla M,Mishra S,Anand K,Parikh P,Mehta M,Vij M,Verma T,Singh P,Jakkala K,Verma HN,AjitKumar P,Ganguli M,Narain Seshasayee AS,Singh A

更新日期：2018-10-01 00:00:00

abstract：:NRF2 is a redox-responsive transcription factor that regulates expression of cytoprotective genes via its interaction with DNA sequences known as antioxidant response elements (AREs). NRF2 activity is induced by oxidative stress, but oxidative stress is not the only context in which NRF2 can be activated. Mutations th...

journal_title：Redox biology

authors： Levings DC,Wang X,Kohlhase D,Bell DA,Slattery M

更新日期：2018-10-01 00:00:00

abstract：:Artesunate (ART) is a prominent anti-malarial with significant anti-cancer properties. Our previous studies showed that ART enhances lysosomal function and ferritin degradation, which was necessary for its anti-cancer properties. ART targeting to mitochondria also significantly improved its efficacy, but the effect of...

journal_title：Redox biology

authors： Zhang J,Sun X,Wang L,Wong YK,Lee YM,Zhou C,Wu G,Zhao T,Yang L,Lu L,Zhong J,Huang D,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5...

journal_title：Redox biology

authors： Jiang X,Liu Y,Liu X,Wang W,Wang Z,Hu Y,Zhang Y,Zhang Y,Jose PA,Wei Q,Yang Z

更新日期：2018-10-01 00:00:00

abstract：:Tumorigenesis is commonly known as a complicated process, in which reactive oxygen species (ROS) plays a critical role to involve in signal transduction, metabolism, cell proliferation and differentiation. Previously, ribosomal protein L10 (RPL10) was suggested to possess extra-ribosomal functions in pancreatic cancer...

journal_title：Redox biology

authors： Yang J,Chen Z,Liu N,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:Bupivacaine is frequently administered for diagnosing and controlling spine-related pain in interventional spine procedures. However, the potential cytotoxic effects of bupivacaine on intervertebral disc (IVD) cells and the underlying molecular mechanisms have not yet been fully established. Here, we showed that bupiv...

journal_title：Redox biology

authors： Cai X,Liu Y,Hu Y,Liu X,Jiang H,Yang S,Shao Z,Xia Y,Xiong L

更新日期：2018-09-01 00:00:00

abstract：:The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. Howeve...

journal_title：Redox biology

authors： van 't Erve TJ

更新日期：2018-07-01 00:00:00

abstract：:Cellular senescence plays essential roles in tissue homeostasis as well as a host of diseases ranging from cancers to age-related neurodegeneration. Various molecular pathways can induce senescence and these different pathways dictate the phenotypic and metabolic changes that accompany the transition to, and maintenan...

journal_title：Redox biology

authors： Plafker KS,Zyla K,Berry W,Plafker SM

更新日期：2018-07-01 00:00:00

abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...

journal_title：Redox biology

authors： Hou D,Liu Z,Xu X,Liu Q,Zhang X,Kong B,Wei JJ,Gong Y,Shao C

更新日期：2018-07-01 00:00:00

abstract：:Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research fo...

journal_title：Redox biology

authors： Liu R,Cao P,Ren A,Wang S,Yang T,Zhu T,Shi L,Zhu J,Jiang AL,Zhao MW

更新日期：2018-06-01 00:00:00

abstract：:Natural products are characterized by extreme structural diversity and thus they offer a unique source for the identification of novel anti-tumor agents. Herein, we report that the herbal substance acteoside being isolated by advanced phytochemical methods from Lippia citriodora leaves showed enhanced cytotoxicity aga...

journal_title：Redox biology

authors： Cheimonidi C,Samara P,Polychronopoulos P,Tsakiri EN,Nikou T,Myrianthopoulos V,Sakellaropoulos T,Zoumpourlis V,Mikros E,Papassideri I,Argyropoulou A,Halabalaki M,Alexopoulos LG,Skaltsounis AL,Tsitsilonis OE,Aligiannis NN,T

更新日期：2018-06-01 00:00:00

abstract：:Necroptosis has been discovered as a new paradigm of cell death and may play a key role in heart disease and selenium (Se) deficiency. Hence, we detected the specific microRNA (miRNA) in response to Se-deficient heart using microRNAome analysis. For high-throughput sequencing using Se-deficient chicken cardiac tissue,...

journal_title：Redox biology

authors： Yang T,Cao C,Yang J,Liu T,Lei XG,Zhang Z,Xu S

更新日期：2018-05-01 00:00:00

abstract：:The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular...

journal_title：Redox biology

authors： Selvaggio G,Coelho PMBM,Salvador A

更新日期：2018-05-01 00:00:00

abstract：:Exposure to (bi)sulfite (HSO3-) and sulfite (SO32-) has been shown to induce a wide range of adverse reactions in sensitive individuals. Studies have shown that peroxidase-catalyzed oxidation of (bi)sulfite leads to formation of several reactive free radicals, such as sulfur trioxide anion (.SO3-), peroxymonosulfate (...

journal_title：Redox biology

authors： Kumar A,Triquigneaux M,Madenspacher J,Ranguelova K,Bang JJ,Fessler MB,Mason RP

更新日期：2018-05-01 00:00:00

abstract：:Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...

journal_title：Redox biology

authors： Chalker J,Gardiner D,Kuksal N,Mailloux RJ

更新日期：2018-05-01 00:00:00

abstract：:Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration. However, bioavailable levels of H2S in its various biochemica...

journal_title：Redox biology

authors： Rajpal S,Katikaneni P,Deshotels M,Pardue S,Glawe J,Shen X,Akkus N,Modi K,Bhandari R,Dominic P,Reddy P,Kolluru GK,Kevil CG

更新日期：2018-05-01 00:00:00

abstract：:Sporadic cases account for 90-95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism. Progressive Supranuclear Palsy (PSP) belongs to the atypical parkinsonian diseases and is histopathologically classified as a tauopathy. Here, we report ...

journal_title：Redox biology

authors： Angelova PR,Barilani M,Lovejoy C,Dossena M,Viganò M,Seresini A,Piga D,Gandhi S,Pezzoli G,Abramov AY,Lazzari L

更新日期：2018-04-01 00:00:00

abstract：:Oxidative stress is reported to regulate several apoptotic and necrotic cell death pathways in auditory tissues. Poly(ADP-ribose) polymerase-1 (PARP-1) can be activated under oxidative stress, which is the hallmark of parthanatos. Autophagy, which serves either a pro-survival or pro-death function, can also be stimula...

journal_title：Redox biology

authors： Jiang HY,Yang Y,Zhang YY,Xie Z,Zhao XY,Sun Y,Kong WJ

更新日期：2018-04-01 00:00:00

abstract：:Increased permeability of the intestinal barrier is proposed as an underlying factor for obesity-associated pathologies. Consumption of high fat diets (HFD) is associated with increased intestinal permeabilization and increased paracellular transport of endotoxins which can promote steatosis and insulin resistance. Th...

journal_title：Redox biology

authors： Cremonini E,Wang Z,Bettaieb A,Adamo AM,Daveri E,Mills DA,Kalanetra KM,Haj FG,Karakas S,Oteiza PI

更新日期：2018-04-01 00:00:00

abstract：:Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast cells. Although the mechanisms causing this activation are not completely understood, it is as...

journal_title：Redox biology

authors： Alsina D,Ros J,Tamarit J

更新日期：2018-04-01 00:00:00

abstract：:Products of ultraviolet (UV) irradiation such as reactive oxygen species (ROS) and nitric oxide (NO) stimulate melanin synthesis. Reactive sulfur species (RSS) have been shown to have strong ROS and NO scavenging effects. However, the instability and low retention of RSS limit their use as inhibitors of melanin synthe...

journal_title：Redox biology

authors： Ikeda M,Ishima Y,Kinoshita R,Chuang VTG,Tasaka N,Matsuo N,Watanabe H,Shimizu T,Ishida T,Otagiri M,Maruyama T

更新日期：2018-04-01 00:00:00

abstract：:Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and ca...

journal_title：Redox biology

authors： Kanaan GN,Ichim B,Gharibeh L,Maharsy W,Patten DA,Xuan JY,Reunov A,Marshall P,Veinot J,Menzies K,Nemer M,Harper ME

更新日期：2018-04-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present stud...

journal_title：Redox biology

authors： Liu S,Xin D,Wang L,Zhang T,Bai X,Li T,Xie Y,Xue H,Bo S,Liu D,Wang Z

更新日期：2017-10-01 00:00:00

abstract：:Coronary artery disease (CAD) is the primary critical cardiovascular event. Endothelial cell and monocyte dysfunction with subsequent extravagant inflammation are the main causes of vessel damage in CAD. Thus, strategies that repress cell death and manage unsuitable pro-inflammatory responses in CAD are potential ther...

journal_title：Redox biology

authors： Chan SH,Hung CH,Shih JY,Chu PM,Cheng YH,Lin HC,Tsai KL

更新日期：2017-10-01 00:00:00

abstract：:Highly active anti-retrovirus therapy (HAART) has been used to block the progression and symptoms of human immunodeficiency virus infection. Although it decreases morbidity and mortality, clinical use of HAART has also been linked to various adverse effects such as severe cardiomyopathy resulting from compromised mito...

journal_title：Redox biology

authors： Nomura R,Sato T,Sato Y,Medin JA,Kushimoto S,Yanagisawa T

更新日期：2017-10-01 00:00:00

abstract：:Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) occurs through the reversible oxidation of cysteine thiol groups, resulting ...

journal_title：Redox biology

authors： Smith KA,Waypa GB,Schumacker PT

更新日期：2017-10-01 00:00:00

abstract：:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades,...

journal_title：Redox biology

authors： Lefaki M,Papaevgeniou N,Chondrogianni N

更新日期：2017-10-01 00:00:00

abstract：:Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we fou...

journal_title：Redox biology

authors： Shin D,Kim EH,Lee J,Roh JL

更新日期：2017-10-01 00:00:00